Medicines Used for Opiate Detoxification
Methadone


Methadone is a rigorously well-tested medication thatis safe and efficacious for the treatment of narcoticwithdrawal and dependence. For more than 30 yearsthis synthetic narcotic has been used to treat opioidaddiction. Heroin releases an excess of dopamine inthe body and causes users to need an opiate continu-ously occupying the opioid receptor in the brain.Methadone occupies this receptor and is the stabilizingfactor that permits addicts on methadone to changetheir behavior and to discontinue heroin use.

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Buprenorphine SUBUTEX

Buprenorphine (Subutex) is a partial agonist. It is a sublingual medication, placed under the tongue to dissolve. It has properties of both agonists and antagonists at the opiate receptor site. This pharmacological profile means that buprenorphine has a lower re-enforcing potential than agonists such as heroin and therefore a lower street value and a lower abuse potential.


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Naltrexone NALOREX

After completing an opiate detox satisfactorily, Naltrexone can be prescribed for abstinence maintenance.
Naltrexone pharmacological action consists in blocking opiate receptors for up to 72 hours without producing the intense effects of opiates, and avoiding this to act if taken.
Naltrexone comes in 50 mg tablets taken orally and blocks the effects of all opiates for up to 72 hours.


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SUBOXONE

This products represents a new formulation of buprenorphine. Suboxone contains both buprenorphine and the opiate antagonist naloxone, and is intended to be the formulation used in maintenance treatment of opiate addiction.
Naloxone has been added to Suboxone to guard against intravenous abuse of buprenorphine by individuals physically dependent on opiates.
Suboxone supplied in 2 mg and 8 mg tablets which is placed under the tongue and must be allowed to dissolve.


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Lofexidine BRITLOFEX

What is Lofexidine and how does it work?
Lofexidine in the treatment of opiate withdrawal
Lofexidine is a non opiate treatment which is used for the management of withdrawal symptoms in patients undergoing opiate detoxification. It is effective in reducing the symptoms associated with opiate withdrawal or "cold turkey" such as chills, sweating, stomach cramps, diarrhoea, muscle pain, runny nose and eyes.
Lofexidine is not an opiate and is non-addictive, it does not give rise to withdrawal symptoms of it’s own.


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